Sperm release hyaluronidase to break down the bonds between adjacent follicle cells surrounding the oocyte.
In mammalian fertilization, the sperm cell's acrosome releases hyaluronidase after reaching the oocyte, breaking down hyaluronan in the corona radiata to enable conception.
Sperm hyaluronidase has been linked to sperm penetration of the cumulus oophorus' extracellular matrix and may be extremely important for gamete contact and mammalian reproduction.
The hyaluronidase enzymes on the surface of the sperm help it break through this covering when a capacitated sperm reaches the ovum.
When this happens, the sperm might connect to the zona pellucida. Hyaluronidase breaks the egg's vitelline membrane as part of its function.
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